1960's--this is easy. Elizabeth Montgomery, immortalized forever as Samantha from "Bewitched." No one else even close, except maybe when she played Serena, her black haired twin sister. HONORABLE MENTION: Barbara Eden from "Genie."
1970's--Pam Ewing from "Dallas." Principally speaking.
1980's--Pass. I hate the 80's.
1990's--Patricia Heaton from "Everybody Loves Raymond." When pussy needs eatin', I'm thinkin' of Heaton." HONORABLE MENTION: Both Claire and Kate from "Lost," although I'm not sure they were wives. Also, Jennifer Aniston from "Friends."
2000's--We have a tie! Rita from "Dexter" and Nancy from "Weeds." HONORABLE MENTION: Claire and Gloria from "Modern Family" and Cheryl Hines from "Curb Your Enthusiasm." She's so hot, and he's so not. Makes her look even better. And then there's January Jones from "Mad Men..."