There is a sticky thread here:
https://www.eccie.net/showthread.php?t=167105
that will give you some good ideas of the various areas of Houston and some good places to stay and some to avoid.
Basically there is Downtown, The Galleria, The Energy Corridor and areas by the airports. These are the most common, but there are other areas to consider.
Best of luck should you decide to tour our city.