https://www.fda.gov/drugs/medication...rug-ingredient Originally Posted by majorjonesThat's really hard to hear because honestly I've been a tad bit hesitant about dealing with Cialis when I heard it possibly can cause blood clots in your lower extremities. To say the least that's enough to give one pause because blood clots in your legs is nothing to scoff at. Anyone no of anything thats more natural and safe?