What area and what type of food?
Downtown area is full of restaurants. Calecos is good, Ruth Chris or Mike Shannon's for steaks, Tony's for a very elegant meal (They have a dress code). Lots of BBQ places. The HIll area is know for Italian. Park Ave for coffee and Gooey butter cake.
Here is a list of our local food critic's top 100 list
http://graphics.stltoday.com/apps/stl100/