The
W Hotel of the Domain area rocks. Great club, and 2 block walk to awesome high end shopping and dining. Enough traffic that nobody stands out.
There is a little known
Holiday Inn Northwest that I have come to like because of how low key and out of view it is.
This
Google Link will give you the Arboretum/Domain area everyone is referencing. Think of it as the Galleria area of Houston, just a bit smaller with alot more trees. In the area you can find Hyatt House (another good choice as it has several buildings with independent entrances), Townplace Suites, Extended Stays, etc. I don't recommend the Renaissance Hotel as the parking and entrance into the hotel and elevators is VERY exposed. I would not visit the location, as they also are a common event venue for local functions.
If you feel you must be on the IH-35 corridor, I suggest
Orangewood Suites. It is a block off the service road, behind a DoubleTree Hotel, and several very respectable restaurants. It is quite, classy enough, low traffic, and low visibility. I have had some GREAT meetups there. Technically, it falls right outside the no-fly zone of IH-35 that many are warning you of, yet easy access, and off the radar.
I hope this is helpful, enjoy your stay. To FWR's point about F1, they are referring to the Formula One international road race. It has already virtually doubled room rates from New Braunfels (south) to Georgetown (north) for about a week prior to the race, through the actual race dates of Nov 16-18. If you can secure lodging, there will be a lot of international high rollers in town that a motivated provider may be able to capitalize on. Just don't expect much from locals during that time.