I have four teams... they went 3-1 over the weekend.
For me week one is the hardest week. You never really know if you started the right lineup. Sure, you've seen the preseason games, but they are not really any measurement for what goes on during the regular season. It will get easier from here because I can scour the waiver wire for talent and spot trends.
I WOULDN'T have predicted Matt Forte to have a big weekend... but a couple of people came up to me at work yesterday and asked "Who is this Arian Foster guy?" I started him in two of the leagues that I have.