Many of you know that I suffered a major injury in September when I crashed my speed bike hitting the pavement at 30+mph, busted kneecap, broken clavicle and torn tricep and bicep. I was locked in the bike when it happened and my whole right side hit, and hit very hard. Ive refused surgery on the arm, I do not want to go under the knife as it would put me out of work for a while. My job requires travel and assisting others physically. Since I have to be on the go all the time, I suffer at night when I lay down to go to sleep, even waking up in excrutiating(sp??) pain. I can NOT take drugs, I dont like the way they make me feel--groggy and out of it. And I have a heart murmur, so prednisone is out of the question. Cortisone shots have been exhausted. Ive tried the pain patches, pm meds, cold and hot rubs, and so many things. I know there are docs on the board here or just anyone with some old fashioned remedies would be great. Dont suggest massage, I tried that with the best hands on the northshore and he about killed me, even his light touch was very painful.
Ive been in rehab training for a month now, and not so sure I havent snapped the clavicle and my breastbone is popping in and out--painfully.
I dont mean to whine, Im usually pretty tough. Ive kept up at work, without showing how much I hurt, but at the end of the day Im in tears.
I want to try anything within reason, holistic or whatever is suggested that I havent done. I dont even get on here much to type since lately the pain has traveled to the fingertips as well. Getting a manicure the other day was painful. GRRRR
I hope everyone is doing fine, and rooting for the home team tomorrow.
Good luck to you all!
xoxo
chella
- Guest031210-2
- 02-06-2010, 10:29 PM
- CuriousMe
- 02-06-2010, 11:31 PM
Well I knew that BMS 560 class would come in handy one day. The pain you experienced when the wreck first happened was what they consider acute pain. This had to do primarily with your neurons without the supporting other nervous cells such as microglia, astrocytes what is considered to be glia cells. After these cells pickup the messages from the activated primary neurons by constant activation from the initial injury. This is done by K+ ions from the neurons along with NO, Glutamate and ATP from the surface receptors.
Long story short, after the initial injury the neurons lose most of the pain signals from the injury. It is the supporting Glia cells that keep the sensation of pain going, which is then considered to be chronic or neuropathic pain, and this is the pain that you are feeling now. This is brought about by increasing the number of microglia and increasing the size of the astrocytes. Once this happens these supporting cells then begin to dispense neurotransmitters to augment the original neuron signals from the site of injury.
These glia cells are responsible for the long term pain as well as any tolerance to morphine based pain medications.
Self cure-smoke lots of marijuana. It possess substances that mimic cannabinoids, which block CB-2 pain receptors. There are a handful of drugs that are designed to decrease the activity of the supporting glia cells. Some of these include AV411, Minocycline, Propentofylline, SLC022, Sativex and the body's own Interleukin's 2 & 10. I'm not sure what class of drugs these are, but I'm pretty sure they are not morphine derivatives. This more than likely didn't help you out, but now you may have a better understanding of the process of lingering pain.
Long story short, after the initial injury the neurons lose most of the pain signals from the injury. It is the supporting Glia cells that keep the sensation of pain going, which is then considered to be chronic or neuropathic pain, and this is the pain that you are feeling now. This is brought about by increasing the number of microglia and increasing the size of the astrocytes. Once this happens these supporting cells then begin to dispense neurotransmitters to augment the original neuron signals from the site of injury.
These glia cells are responsible for the long term pain as well as any tolerance to morphine based pain medications.
Self cure-smoke lots of marijuana. It possess substances that mimic cannabinoids, which block CB-2 pain receptors. There are a handful of drugs that are designed to decrease the activity of the supporting glia cells. Some of these include AV411, Minocycline, Propentofylline, SLC022, Sativex and the body's own Interleukin's 2 & 10. I'm not sure what class of drugs these are, but I'm pretty sure they are not morphine derivatives. This more than likely didn't help you out, but now you may have a better understanding of the process of lingering pain.
- Guest031210-2
- 02-07-2010, 09:35 AM
Oddly enough,call me a geak, I understood it. I dont do drugs or smoke anything, so Im going to stick to advice given to me thru a few pm's. Im the kind of person if I take a daytime niquil I pass out for 24 hours. haha. But thank you anyway. Very sweet of ya.
xoxo
xoxo
- pornodave69
- 02-07-2010, 11:01 AM
Get the surgery.
- reflex happens
- 02-07-2010, 12:39 PM
My mother was the victim of a hit and run. She really messed up her back and neck and the doctors told her that her only option was to have an operation. Being the active person that she is she looked of other forms of treatment. She was told by one of my family members who is a nurse to try acupuncture. The acupuncture really helped with the pain for a few years, but the problem got worse over time and she ended up getting the operations. I'm not sure where you live but if you are anywhere close to Baton Rouge you can send me a P.M. and I will find out who she saw for the acupuncture. I hope this helps and that you get better.
Reflex
Reflex