Business Insider Don't hold your breath for a coronavirus vaccine. Here are the 7 biggest challenges we still need to overcome.

https://www.msn.com/en-us/health/med...96U?li=BBorjTa


An overview article - refreshingly not politicized - on issues with a wuhan virus vaccine.



Don't hold your breath for a coronavirus vaccine. Here are the 7 biggest challenges we still need to overcome.









If a fire breaks out in a school or a movie theater, everyone knows what to do: head for the exits.

What's certain is that a vaccine is crucial. That's why scientists and governments are working at unprecedented speeds to create one. Since the start of the outbreak, top health officials have said it'll take about 12-18 months for a vaccine to be ready. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, has said he's "optimistic" that we'll have at least one vaccine ready by the end of this year or the start of 2021.
But even that timeline is unknown.
"When you're dealing with vaccines, you can't guarantee things," Fauci told PBS NewsHour in a July 17 interview.
Plus, even once we create a promising vaccine, big challenges to humanity's exit strategy come after that: in testing, mass-manufacturing, and distributing these vaccines fairly and affordably. More insidious political and cultural barriers may also arise, since even if a vaccine is produced and distributed in record time, many Americans say they won't opt in.
Where things stand now

Progress to date looks good: More than 150 coronavirus vaccine programs are underway. While the majority are still being developed on laboratory benchtops, about two dozen are already being testing in people.
The frontrunners, from Moderna, Pfizer, and AstraZeneca, are on the verge of kicking off clinical trials that will enroll tens of thousands of volunteers to help determine whether the shots prevent coronavirus infections or enable people to fight off the virus if they do get sick.

Pharmaceutical giant Merck is also working on a coronavirus shot but hasn't provided details on when it might be ready.

"I think when people tell the public that there's going to be a vaccine by the end of 2020, for example, I think they do a grave disservice," Kenneth Frazier, Merck's CEO, said in a recent interview with Harvard professor Tsedal Neeley. "We don't have a great history of introducing vaccines quickly in the middle of a pandemic. We want to keep that in mind."
Here are the seven major questions that need to be answered before a coronavirus shot is within reach.
Is the vaccine safe?

© Zhang Yuwei/Xinhua via AP A staff member tests samples of a potential COVID-19 vaccine at a production plant of SinoPharm. Zhang Yuwei/Xinhua via AP Because vaccines are designed to prevent disease in people who aren't sick, regulators, doctors, and the public have little tolerance for side effects, particularly lasting or damaging ones.
Early coronavirus vaccine safety tests, done in small groups of young, healthy people, so far show that the majority of vaccinated volunteers experience some mild side effects, such as fevers, fatigue, and pain at the injection site.
That raises questions about whether people who are older or who have preexisting health conditions — those who need protection from COVID-19 the most — will tolerate these shots as well as the test groups. Additional trials are underway in larger groups of people, including the elderly and people with comorbidities.

When vaccine candidates get tested in tens of thousands of people, it's possible we'll learn about additional problems, including ultra-rare but serious side effects that have hindered some previous vaccine programs. There's also a theoretical risk that a vaccine could make the disease worse in some people, a phenomenon called antibody-dependent enhancement.

Does the vaccine work?

The answer to this question is probably more complicated than a simple yes or no.
A perfect vaccine would be 100% effective at preventing viral infections. But no vaccine developer expects this to be the case with COVID-19. The US Food and Drug Administration has said it wants to see at least 50% effectiveness before it approves a shot.
© David L. Ryan/The Boston Globe via Getty Images Moderna offices in Cambridge, Massachusetts. David L. Ryan/The Boston Globe via Getty Images A coronavirus vaccine could wind up being partially effective, like the flu shot, meaning it reduces the likelihood that people who get the shot develop serious symptoms.
Moderna, for instance, has designed its big human trial to detect whether its coronavirus vaccine can achieve at least a 60% reduction in symptomatic disease.
So even with a vaccine, it's likely that there will be some coronavirus that continues to circulate in society.
Will protection from a vaccine fade over time?

© Thomas Peter/Reuters A test tube containing coronavirus antibodies. Thomas Peter/Reuters Vaccines are created to prompt your body to generate antibodies that protect you from future infection.
Companies like Moderna, Pfizer, and AstraZeneca have compared their vaccines to a sampling of recovered COVID-19 patients in early studies. The results have shown that the shots generate an antibody response that's at least as strong as what a typical COVID-19 survivor's body naturally develops.
But some research suggests coronavirus antibodies don't last very long — one study suggested antibodies might last only three to five weeks in some patients. If antibodies are really that fleeting, a vaccine's protection could be short-lived, too.
Still, experts say that's no cause for panic, since our body's immunity isn't just tied to antibodies. White blood cells have an impressive immunological memory that can help the body identify and attack the invading virus should it ever return. T cells can destroy infected cells, and B cells work to produce new antibodies. A vaccine could help create both.
"There's no evidence that immunity is fleeting and no rigorous estimates yet of how long it will last," Marm Kilpatrick, a disease ecologist at University of California Santa Cruz, told Business Insider.
© Andrew Caballero-Reynolds/AFP Dr. Rhonda Flores looks at protein samples at Novavax labs, one of the labs developing a vaccine for the coronavirus, in Gaithersburg, Maryland on March 20, 2020. Andrew Caballero-Reynolds/AFP And even if antibodies wane over time, that's not a deal breaker for a vaccine, according to Florian Krammer, a vaccinologist at the Icahn School of Medicine at Mount Sinai.
"This happens for a lot of vaccines," he previously told Business Insider. "It's not a problem. You can get revaccinated."
Many vaccines have to be given repeatedly, or boosted, at some point in a person's life.
"To be quite honest, the least of our problems is, 'Do we have a vaccine that is going to last us for years?'" Maria Elena Bottazzi, a vaccine developer at Baylor College of Medicine, told Business Insider.
Can we mass-produce it?

Say a vaccine is found to be safe and effective for widespread use. Then comes another huge challenge: developers will have to make massive quantities of it.
The leading vaccines use several different technologies — such as mRNA, recombinant protein, and adenoviruses —each of which has its own complex manufacturing process. While all the leading vaccine developers have been scaling up their production capabilities, none will be able to meet worldwide demand anytime soon.
© David L. Ryan/The Boston Globe/Getty Images Scientist Xinhua Yan works in the lab at Moderna in Cambridge, Massachusetts, on February 28, 2020. David L. Ryan/The Boston Globe/Getty Images Constraining supplies further, Moderna, AstraZeneca, and Pfizer all say their vaccines will require people to get two shots a few weeks apart.
What's more, when vaccine vials come off the factory line, the last mile of their journey may be the hardest. Some of the candidates, such as Moderna's and Pfizer's, need to be kept in freezers or refrigerators to work. Moderna's vaccine, for instance, needs to be stored at minus 4 degrees Fahrenheit.
That will pose a formidable infrastructure issue for the developing world, particularly in places where electricity or established health systems are not widespread.
Still, world governments have already committed billions to scale up vaccine production.
When will we really have a vaccine?

Having a vaccine is a mushy concept: Do we "have a vaccine" when one succeeds in clinical trials? Or when it's approved by regulators? Or only once there are enough doses available to inoculate the world?
It's possible that a vaccine could secure emergency use authorization from the FDA in the US as soon as this fall, but that doesn't mean it would be widely available.
According to David Heymann, an epidemiologist and advisor to the World Health Organization, it's likely that those first limited doses will go to the swaths of the population at greatest risk of infection.
"This would likely be health workers and carers, persons with comorbidities and the elderly," he said. "After that other populations would likely be considered provided there is sufficient vaccine."
The Trump administration has set a goal of having 300 million doses of a vaccine by January.
© Ted S. Warren/Associated Press A Seattle pharmacist gives Jennifer Haller the first shot in the first-stage safety study clinical trial of a potential vaccine for coronavirus on March 16, 2020. Ted S. Warren/AP There's no detailed timetable for how to inoculate the world, but getting any vaccine to the entire planet will take at least several years, if not longer. Groups like Gavi and the World Health Organization are creating a framework to ensure the developing world is not left behind.
Once we have a vaccine, will people want to get it?

Even if the US winds up ready to start vaccinating lots of people in early 2021, it's not clear how many people would trust the shots. Scientists and some politicians have struggled for months to convince chunks of the American public that masks are worth wearing.
Winning over vaccine skeptics will likely be even more challenging. Doing so requires the public to trust the drug companies that developed the shot, the research system that vetted it in trials, and the Trump administration regulators that approved it — all of which would have happened in record time.
In a recent poll, about one in five Americans said they don't plan to get a coronavirus vaccine, while half said they would. The rest were unsure.
© AP Photo / Sang Tan An anti-vaxxer protest in the UK. AP Photo / Sang Tan Another barrier could be the cost. An early coronavirus bailout bill requires US health insurers to eventually cover a coronavirus vaccine, though that might not happen immediately. The US has also vowed to make a coronavirus vaccine free to "vulnerable" Americans, but the details aren't clear. The government announced this month, however, that it would make one potential coronavirus vaccine, from Pfizer, available at no cost to individuals.
What about booster shots?

Given that people will likely need to get two shots of a coronavirus vaccine a few weeks apart for it to be effective, healthcare systems in all countries will have to ensure that people come back for the second dose — which is sure to be a challenge.
"The more complicated the schedule, the more difficult it is to get people to come in," Walt Orenstein, a vaccinologist and former director of the US National Immunization Program, told Business Insider.
Two required shots also means we'll need twice as many vials, syringes, clinic visits, and so on.
Those challenges would only snowball if it turns out that people need to get revaccinated regularly.
Vaccines aren't the only game in town

© Kevin Dietsch/Pool via REUTERS Dr. Anthony Fauci, director of the National Institute for Allergy and Infectious Diseases, puts on a Washington Nationals face mask when he arrives to testify before the House Committee, on Capitol Hill in Washington DC, June 23, 2020. Kevin Dietsch/Pool via REUTERS Despite the exuberance we've seen around many vaccine programs' promising early results, experts have been pretty clear that even a coronavirus vaccine won't return bring pre-pandemic life back overnight.
"Given public-health infrastructure, I doubt anyone is reasonably expecting we can eliminate the virus globally with vaccine," Kilpatrick said. "It likely will be with us long term."




Still, doctors are learning how to better care for coronavirus patients. Drugmakers have already identified treatments that can help people recover more quickly and reduce deaths in severely ill COVID-19 patients.

New, experimental therapeutics could improve patient outcomes even more dramatically. In particular, antibody drugs are now being tested in humans to see if they can treat COVID-19 as well as prevent infections among high-risk people. If they work, some could be ready this fall — before a vaccine.
In a July 14 livestream hosted by Stanford University, Fauci said as much.

"What we really need, and we're on the track of getting, are interventions that can be given early in the course of disease to prevent people who are vulnerable from progressing to the requirement for hospitalization," he said, adding, "I believe we are on a good track to get there reasonably soon."

A lot of truth in that article. Need an effective vaccine to protect the masses from getting infected.

Until that happens the roller coaster in cases will simply continue.....stay at home followed by the numbers are down, open the bars and beaches, people congregate, numbers go way back up....order everybody to stay home again.

Too many people act like "it's over"....or "it happens to someone else, not me"....I know a couple of people who think corona is just simply a bunch of bullshit and go about their lives as if it doesn't exist......there's still like 800 people a day dying in this country alone.

Without a vaccine it's always going to be March/April 2020 out there.

https://www.msn.com/en-us/health/med...96U?li=BBorjTa


An overview article - refreshingly not politicized - on issues with a wuhan virus vaccine.



Don't hold your breath for a coronavirus vaccine. Here are the 7 biggest challenges we still need to overcome.









If a fire breaks out in a school or a movie theater, everyone knows what to do: head for the exits.

What's certain is that a vaccine is crucial. That's why scientists and governments are working at unprecedented speeds to create one. Since the start of the outbreak, top health officials have said it'll take about 12-18 months for a vaccine to be ready. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, has said he's "optimistic" that we'll have at least one vaccine ready by the end of this year or the start of 2021.
But even that timeline is unknown.
"When you're dealing with vaccines, you can't guarantee things," Fauci told PBS NewsHour in a July 17 interview.
Plus, even once we create a promising vaccine, big challenges to humanity's exit strategy come after that: in testing, mass-manufacturing, and distributing these vaccines fairly and affordably. More insidious political and cultural barriers may also arise, since even if a vaccine is produced and distributed in record time, many Americans say they won't opt in.
Where things stand now

Progress to date looks good: More than 150 coronavirus vaccine programs are underway. While the majority are still being developed on laboratory benchtops, about two dozen are already being testing in people.
The frontrunners, from Moderna, Pfizer, and AstraZeneca, are on the verge of kicking off clinical trials that will enroll tens of thousands of volunteers to help determine whether the shots prevent coronavirus infections or enable people to fight off the virus if they do get sick.

Pharmaceutical giant Merck is also working on a coronavirus shot but hasn't provided details on when it might be ready.

"I think when people tell the public that there's going to be a vaccine by the end of 2020, for example, I think they do a grave disservice," Kenneth Frazier, Merck's CEO, said in a recent interview with Harvard professor Tsedal Neeley. "We don't have a great history of introducing vaccines quickly in the middle of a pandemic. We want to keep that in mind."
Here are the seven major questions that need to be answered before a coronavirus shot is within reach.
Is the vaccine safe?

© Zhang Yuwei/Xinhua via AP A staff member tests samples of a potential COVID-19 vaccine at a production plant of SinoPharm. Zhang Yuwei/Xinhua via AP Because vaccines are designed to prevent disease in people who aren't sick, regulators, doctors, and the public have little tolerance for side effects, particularly lasting or damaging ones.
Early coronavirus vaccine safety tests, done in small groups of young, healthy people, so far show that the majority of vaccinated volunteers experience some mild side effects, such as fevers, fatigue, and pain at the injection site.
That raises questions about whether people who are older or who have preexisting health conditions — those who need protection from COVID-19 the most — will tolerate these shots as well as the test groups. Additional trials are underway in larger groups of people, including the elderly and people with comorbidities.

When vaccine candidates get tested in tens of thousands of people, it's possible we'll learn about additional problems, including ultra-rare but serious side effects that have hindered some previous vaccine programs. There's also a theoretical risk that a vaccine could make the disease worse in some people, a phenomenon called antibody-dependent enhancement.

Does the vaccine work?

The answer to this question is probably more complicated than a simple yes or no.
A perfect vaccine would be 100% effective at preventing viral infections. But no vaccine developer expects this to be the case with COVID-19. The US Food and Drug Administration has said it wants to see at least 50% effectiveness before it approves a shot.
© David L. Ryan/The Boston Globe via Getty Images Moderna offices in Cambridge, Massachusetts. David L. Ryan/The Boston Globe via Getty Images A coronavirus vaccine could wind up being partially effective, like the flu shot, meaning it reduces the likelihood that people who get the shot develop serious symptoms.
Moderna, for instance, has designed its big human trial to detect whether its coronavirus vaccine can achieve at least a 60% reduction in symptomatic disease.
So even with a vaccine, it's likely that there will be some coronavirus that continues to circulate in society.
Will protection from a vaccine fade over time?

© Thomas Peter/Reuters A test tube containing coronavirus antibodies. Thomas Peter/Reuters Vaccines are created to prompt your body to generate antibodies that protect you from future infection.
Companies like Moderna, Pfizer, and AstraZeneca have compared their vaccines to a sampling of recovered COVID-19 patients in early studies. The results have shown that the shots generate an antibody response that's at least as strong as what a typical COVID-19 survivor's body naturally develops.
But some research suggests coronavirus antibodies don't last very long — one study suggested antibodies might last only three to five weeks in some patients. If antibodies are really that fleeting, a vaccine's protection could be short-lived, too.
Still, experts say that's no cause for panic, since our body's immunity isn't just tied to antibodies. White blood cells have an impressive immunological memory that can help the body identify and attack the invading virus should it ever return. T cells can destroy infected cells, and B cells work to produce new antibodies. A vaccine could help create both.
"There's no evidence that immunity is fleeting and no rigorous estimates yet of how long it will last," Marm Kilpatrick, a disease ecologist at University of California Santa Cruz, told Business Insider.
© Andrew Caballero-Reynolds/AFP Dr. Rhonda Flores looks at protein samples at Novavax labs, one of the labs developing a vaccine for the coronavirus, in Gaithersburg, Maryland on March 20, 2020. Andrew Caballero-Reynolds/AFP And even if antibodies wane over time, that's not a deal breaker for a vaccine, according to Florian Krammer, a vaccinologist at the Icahn School of Medicine at Mount Sinai.
"This happens for a lot of vaccines," he previously told Business Insider. "It's not a problem. You can get revaccinated."
Many vaccines have to be given repeatedly, or boosted, at some point in a person's life.
"To be quite honest, the least of our problems is, 'Do we have a vaccine that is going to last us for years?'" Maria Elena Bottazzi, a vaccine developer at Baylor College of Medicine, told Business Insider.
Can we mass-produce it?

Say a vaccine is found to be safe and effective for widespread use. Then comes another huge challenge: developers will have to make massive quantities of it.
The leading vaccines use several different technologies — such as mRNA, recombinant protein, and adenoviruses —each of which has its own complex manufacturing process. While all the leading vaccine developers have been scaling up their production capabilities, none will be able to meet worldwide demand anytime soon.
© David L. Ryan/The Boston Globe/Getty Images Scientist Xinhua Yan works in the lab at Moderna in Cambridge, Massachusetts, on February 28, 2020. David L. Ryan/The Boston Globe/Getty Images Constraining supplies further, Moderna, AstraZeneca, and Pfizer all say their vaccines will require people to get two shots a few weeks apart.
What's more, when vaccine vials come off the factory line, the last mile of their journey may be the hardest. Some of the candidates, such as Moderna's and Pfizer's, need to be kept in freezers or refrigerators to work. Moderna's vaccine, for instance, needs to be stored at minus 4 degrees Fahrenheit.
That will pose a formidable infrastructure issue for the developing world, particularly in places where electricity or established health systems are not widespread.
Still, world governments have already committed billions to scale up vaccine production.
When will we really have a vaccine?

Having a vaccine is a mushy concept: Do we "have a vaccine" when one succeeds in clinical trials? Or when it's approved by regulators? Or only once there are enough doses available to inoculate the world?
It's possible that a vaccine could secure emergency use authorization from the FDA in the US as soon as this fall, but that doesn't mean it would be widely available.
According to David Heymann, an epidemiologist and advisor to the World Health Organization, it's likely that those first limited doses will go to the swaths of the population at greatest risk of infection.
"This would likely be health workers and carers, persons with comorbidities and the elderly," he said. "After that other populations would likely be considered provided there is sufficient vaccine."
The Trump administration has set a goal of having 300 million doses of a vaccine by January.
© Ted S. Warren/Associated Press A Seattle pharmacist gives Jennifer Haller the first shot in the first-stage safety study clinical trial of a potential vaccine for coronavirus on March 16, 2020. Ted S. Warren/AP There's no detailed timetable for how to inoculate the world, but getting any vaccine to the entire planet will take at least several years, if not longer. Groups like Gavi and the World Health Organization are creating a framework to ensure the developing world is not left behind.
Once we have a vaccine, will people want to get it?

Even if the US winds up ready to start vaccinating lots of people in early 2021, it's not clear how many people would trust the shots. Scientists and some politicians have struggled for months to convince chunks of the American public that masks are worth wearing.
Winning over vaccine skeptics will likely be even more challenging. Doing so requires the public to trust the drug companies that developed the shot, the research system that vetted it in trials, and the Trump administration regulators that approved it — all of which would have happened in record time.
In a recent poll, about one in five Americans said they don't plan to get a coronavirus vaccine, while half said they would. The rest were unsure.
© AP Photo / Sang Tan An anti-vaxxer protest in the UK. AP Photo / Sang Tan Another barrier could be the cost. An early coronavirus bailout bill requires US health insurers to eventually cover a coronavirus vaccine, though that might not happen immediately. The US has also vowed to make a coronavirus vaccine free to "vulnerable" Americans, but the details aren't clear. The government announced this month, however, that it would make one potential coronavirus vaccine, from Pfizer, available at no cost to individuals.
What about booster shots?

Given that people will likely need to get two shots of a coronavirus vaccine a few weeks apart for it to be effective, healthcare systems in all countries will have to ensure that people come back for the second dose — which is sure to be a challenge.
"The more complicated the schedule, the more difficult it is to get people to come in," Walt Orenstein, a vaccinologist and former director of the US National Immunization Program, told Business Insider.
Two required shots also means we'll need twice as many vials, syringes, clinic visits, and so on.
Those challenges would only snowball if it turns out that people need to get revaccinated regularly.
Vaccines aren't the only game in town

© Kevin Dietsch/Pool via REUTERS Dr. Anthony Fauci, director of the National Institute for Allergy and Infectious Diseases, puts on a Washington Nationals face mask when he arrives to testify before the House Committee, on Capitol Hill in Washington DC, June 23, 2020. Kevin Dietsch/Pool via REUTERS Despite the exuberance we've seen around many vaccine programs' promising early results, experts have been pretty clear that even a coronavirus vaccine won't return bring pre-pandemic life back overnight.
"Given public-health infrastructure, I doubt anyone is reasonably expecting we can eliminate the virus globally with vaccine," Kilpatrick said. "It likely will be with us long term."




Still, doctors are learning how to better care for coronavirus patients. Drugmakers have already identified treatments that can help people recover more quickly and reduce deaths in severely ill COVID-19 patients.

New, experimental therapeutics could improve patient outcomes even more dramatically. In particular, antibody drugs are now being tested in humans to see if they can treat COVID-19 as well as prevent infections among high-risk people. If they work, some could be ready this fall — before a vaccine.
In a July 14 livestream hosted by Stanford University, Fauci said as much.

"What we really need, and we're on the track of getting, are interventions that can be given early in the course of disease to prevent people who are vulnerable from progressing to the requirement for hospitalization," he said, adding, "I believe we are on a good track to get there reasonably soon." Originally Posted by oeb11

I think a treatment would be magnificent - then we can get back to living as free men and women.

We now have treatments - remdesivir, budesonide, plasma antibody transfusions, better respiratory care - for the pulmonary issues which kill most wuhan virus patients.


BTW - where is 9500 and his racist old White guy memes on this post????

We now have treatments - remdesivir, budesonide, plasma antibody transfusions, better respiratory care - for the pulmonary issues which kill most wuhan virus patients.


BTW - where is 9500 and his racist old White guy memes on this post???? Originally Posted by oeb11

Maybe one of his relatives got killed by another black person and he realizes we are right?

We now have treatments - remdesivir, budesonide, plasma antibody transfusions, better respiratory care - for the pulmonary issues which kill most wuhan virus patients.


BTW - where is 9500 and his racist old White guy memes on this post???? Originally Posted by oeb11

another one to add to the list, a diabetes drug also work (it starts with F-something). this drug attaches itself to the triglyceride fats. cv19 can't attach to the fatty cells when its present.

I live in Miami-Dade county here in Florida having the dubious title of worst place in America to be right now. It is easy to see why this is, looking at the local nightly news. To many people either think this is all a hoax, think it won't effect them or say the government WILL NOT tell them what to do because THEY have Constitutional rights don't you know. Of course most of them couldn't articulate that so called Constitutional right. They are out gathering by the thousands, parting like there is no tomorrow, which ironically there won't be for a few of them.


Lucky for me, I don't need to work and gave up the bars and partying in groups long ago. In my little neck of the woods, most people are wearing masks because the few places I go require them or you may not enter.


Here, like in New York, the number of deaths in elder care facilities is sky rocketing because even though personnel are suppose to be limited and checked for COVID, it is left up to management and management is doing a piss poor job and not checking on every single person entering these facilities.



People and places that take this seriously will have low numbers. People and places that do not will have high numbers. Right now in Miami-Dade county, people are not taking this serious enough. It really isn't rocket science but as Nancy Pelosi said, "people are going to do what people are going to do" and some of them are going to die. Such is life in the age of pandemic. I'm just glad this didn't happen when I was in my 30's and 40's, still working and a party animal in the bars and clubs every week-end and would probably be acting like the rest of the fools believing it wasn't going to happen to me.


Social distancing happened in a time when I had already been doing that for years. Lucky me.

I think a treatment would be magnificent - then we can get back to living as free men and women. Originally Posted by friendly fred

You're absolutely right. The Vaccine industry makes way too much money on chemical concoctions that maybe more harmful than good in the long run. Besides there's no guarantee that injecting perfectly healthy people with an unknown substance will ward off a disease. It's not just a shot in the arm it's a shot in the dark.

You are free as an adult to go without [polio, diphtheria, typhoid, measles mumps, and other vaccines.

Don't send your kid to school without those vaccinations.

Or, into contact with all the so beloved of the DPST illegal aliens kids who carry many of those diseases.

Which can be lethal.

Polio vaccine - came out in the 1950's. for the history deniers and cancel culture.

I live in Miami-Dade county here in Florida having the dubious title of worst place in America to be right now. It is easy to see why this is, looking at the local nightly news. To many people either think this is all a hoax, think it won't effect them or say the government WILL NOT tell them what to do because THEY have Constitutional rights don't you know. Of course most of them couldn't articulate that so called Constitutional right. They are out gathering by the thousands, parting like there is no tomorrow, which ironically there won't be for a few of them.


Lucky for me, I don't need to work and gave up the bars and partying in groups long ago. In my little neck of the woods, most people are wearing masks because the few places I go require them or you may not enter.


Here, like in New York, the number of deaths in elder care facilities is sky rocketing because even though personnel are suppose to be limited and checked for COVID, it is left up to management and management is doing a piss poor job and not checking on every single person entering these facilities.



People and places that take this seriously will have low numbers. People and places that do not will have high numbers. Right now in Miami-Dade county, people are not taking this serious enough. It really isn't rocket science but as Nancy Pelosi said, "people are going to do what people are going to do" and some of them are going to die. Such is life in the age of pandemic. I'm just glad this didn't happen when I was in my 30's and 40's, still working and a party animal in the bars and clubs every week-end and would probably be acting like the rest of the fools believing it wasn't going to happen to me.


Social distancing happened in a time when I had already been doing that for years. Lucky me. Originally Posted by HedonistForever

I think we should put out a rumor that gay men cannot get COVID-19...of course, it would be terrible to see Luke and WTF and Assup and Mole and the other gays die but we could carry on without them...

Big Phamra is making Billions for a Vaccine that is not effective

Big Phamra is making Billions for a Vaccine that is not effective Originally Posted by rexdutchman

The problem is we don't know how long antibodies will last and thus immunity. The news already reports on a few that have gotten it a second time.


They very well could have a vaccine, but if it only lasts for 6 months who knows how much it will help

You are free as an adult to go without [polio, diphtheria, typhoid, measles mumps, and other vaccines.

Don't send your kid to school without those vaccinations.

Or, into contact with all the so beloved of the DPST illegal aliens kids who carry many of those diseases.

Which can be lethal.

Polio vaccine - came out in the 1950's. for the history deniers and cancel culture. Originally Posted by oeb11

I am not sure how free we are anymore. Especially when guys like Bill Gates talks about Depopulation and Mandatory Vaccines all in one breath.

Sadly this is gonna become mandatory , which will push people over the edge ,,,,,,,,,,,,,,,,,

Sadly this is gonna become mandatory , which will push people over the edge ,,,,,,,,,,,,,,,,, Originally Posted by rexdutchman

It will just increase violent crime. Then Martial Law will be implemented. It's all done by design.