Twisted Root opened a location in Roanoke I would like to try. Tried the one near SMU and it was just as good.
Pappas Burgers is another I like. I enjoy trying different burger places.
JPdM - In n Out is great because of how fresh everything is served. If you like fries they literally go from being a potato to fries in a few minutes. Some places will press their fries locally but they still sit waiting to be cooked. They don't press them until they are ready to go into the fryer.
The burgers, to me, are like Kincaids in that they are simple. They are so fresh it is hard to duplicate for the price.