KC is a weird team, at least according to box scores and stats, I don't think I've seen a single game of theirs all year, but they appear to be one of the worst teams in the league despite having a somewhat respectable defense. I don't think there is any decisive answer at your QB spot, but I would go with Luck, Ryan can be a little off on the road...
At RBs, go with Lynch, should have a big game in prime time, it would be hard not to play AD, you will probably feel stupid if you bench him and he has a big game, he will also get a ton of carries, so there is that. I would probably go with Johnson over law firm, GB will probably have the game won early, and he can get his numbers in garbage time...
Calvin Johnson for sure at WR, Detroit has nothing to play for besides getting him that passing record. I would go with Green and Thomas after that, in that order.