Hi, Kourtney! There are basically 3 good areas with a suitable range of hotel options: Loop 410 in the Airport area; IH-10 West and Wurzbach Road in the Medical Center area; and the intersection of Loop 1604 and Highway 281 North. Avoid Downtown/Riverwalk due to parking hassles. Avoid the Studio version of "We'll keep the lights on for you" due to LE activity.
Welcome to SA! Have fun and stay safe!
Originally Posted by PDid
+1 on everything Pdid said except I would probably avoid the far north side of 1604 and 281 due to traffic but it is safe.
Airport area and medical center are clearly the best choices.