If you're coming to Nola to go sightseeing or to party then the French Quarter is an expensive but good choice. If you're coming here to provide then stay in Metairie or Kenner.
Traffic and parking is a bitch in the FQ on weekends. I'd rather drive 90 miles to BR than deal with the hassles of the Quarter. (Which btw I did that both times I saw you)
She can stay in the CBD & still be convenient to both Le Quartier & Metairie. But Metairie is the popular choice. Baba is right though: if you're not coming to work, but just to party & have a weekend off, you would probably want to stay closer to the Qtr.